This is due to Microsoft Office converting the PDF format placed into the clipboard into an EMF format image thereby losing additional structure information required for round trip editing between the two software applications. Copying and pasting structures from ChemDraw into Word, and then copying and pasting back into ChemDraw results in only the image being pasted back into Word. Microsoft Word 2016 on Mac breaks copy and paste of structures in ChemDraw.Ī recent update in Microsoft Office 2016 for Mac (16.9 released on January 16th 2016) has broken the round trip editing for ChemDraw.